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Descubren una relación entre el ADN y la obesidad. |
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Cerca de siete de cada mil personas que sufren obesidad mórbida carecen de una sección de ADN compuesta por unos treinta genes, según los resultados de un proyecto financiado con fondos comunitarios. Los resultados de este proyecto se han publicado en la revista Nature. Los autores del estudio, pertenecientes al Imperial College de Londres(ICL, Reino Unido) y otros diez centros de investigación europeos, sugieren que la falta de dicha sección de ADN puede influir de forma extraordinaria en el peso de una persona. Estudios anteriores ya habían sacado a relucir algunas variaciones genéticas, principalmente mutaciones sencillas del ADN capaces de modificar la función de un gen, pero esta nueva investigación es la primera en demostrar que la obesidad puede tener su origen en una variación genética poco común. Todavía no se conoce la función de los genes que faltan, pero otros estudios realizados sobre el tema sugieren que pueden guardar relación con retrasos en el desarrollo, la esquizofrenia y el autismo.
Cerca de 700.000 habitantes del Reino Unido padecen obesidad mórbida, determinada por un índice de masa corporal (IMC) de más de 30 cuando lo normal se sitúa entre 18,5 y 25. Se sospecha que uno de cada veinte casos de obesidad mórbida se debe a variaciones genéticas como mutaciones de genes y la ausencia de segmentos de ADN.
Los científicos al cargo de este proyecto plantean la existencia de otras faltas o mutaciones que podrían elevar la probabilidad de padecer obesidad en ciertos grupos de gente. Además, se proponen aprovechar los conocimientos científicos más avanzados para desarrollar pruebas destinadas a seleccionar el mejor tratamiento posible para obesos mórbidos que presenten una mutación o desaparición de una cadena de ADN.
En referencia a los descubrimientos realizados, el profesor Philippe Froguel del ICL comentó que: «El aumento reciente de la obesidad en el mundo desarrollado se debe a un entorno malsano en el que abunda la comida poco saludable y escasea el ejercicio, pero los distintos efectos de este entorno en la gente poseen una base genética en muchos casos.» «Cada vez está más claro que el peso de algunos obesos mórbidos se debe a causas genéticas. Si pudiéramos identificar a estos individuos mediante pruebas genéticas, podríamos ofrecerles apoyo y cuidados médicos adecuados, como por ejemplo la opción de perder peso mediante cirugía, y así mejorar su salud a largo plazo.»
Para empezar, los investigadores identificaron los genes mutados o desaparecidos en adolescentes y adultos con dificultades de aprendizaje o retrasos en el desarrollo. Descubrieron que 31 individuos carecían de casi los mismos genes en una copia de su ADN. El IMC de todos ellos estaba por encima de treinta. A continuación estudiaron el genoma de más de 16.000 personas tanto obesas como de peso normal y descubrieron que 19 individuos del grupo de los obesos presentaban las mismas carencias genéticas por ninguno en el grupo de las personas de peso normal.
Los investigadores confían en que los resultados del estudio sirvan para identificar influencias genéticas en otras enfermedades como la diabetes de tipo 2.
Enviado el Martes, 09 febrero a las 08:48:31 por divulgacioncientifica
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